Texas A&M AgriLife Extension Service is implementing this two-year project to prevent opioid misuse among high school students in rural Texas communities. The project includes implementation of an adapted curriculum based on the Think Smart curriculum that was included in two NIDA-funded PIRE studies (Knowlton Johnson, PI) to reduce misuse of harmful legal products in frontier Alaska communities. The first was a feasibility study of a community prevention model that included environmental strategies and the Think SMART curriculum, and the second was a randomized controlled trial study to test for the effects of the curriculum. As part of the latter study, the researchers found medium-sized effects on reduction in use of harmful legal products.